Inaugural Course on Molecular Toxicology
Molecular toxicology is the discipline that particularly emerged in recent years as a result of the paradigm shift currently going on in the field of toxicology. This shift is the transition from classical toxicology, focusing on endpoints of toxicity in animal models, to predictive in vitro toxicology, relying on information on toxic mechanisms, to more predictive models of computational (in silico) toxicity, replying on analytical tools like Quantitative Structure Activity Relationships (QSAR).
Driven by these recent developments, the Molecular Toxicology Specialty Section within EUROTOX is establishing education and training in this field. The inaugural course (run 26-28 June 2019) presented a series of state-of-the-art lectures related to 4 themes, namely; General principles, Receptor-mediated toxic outcomes, Targets, cellular responses and interventions, and Approaches to toxicity prediction. It is a European Registered Toxicologist (ERT) Course on core topic B4: Molecular and cellular toxicology.
In considering the safety of medical devices and pharmaceuticals (and also other therapeutic agents), understanding the dose response relationships is crucial. Characterising the relationship between exposure and response is fundamental to risk assessment. As an example, one of the current key industry concerns is Endocrine Disruptors and their proposed “low dose toxicity.” As a result, dose and response need to be better understood, which depends on a more mechanistic understanding (of modes of toxicity), rather than just artefact observation.
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